Dibase 100,000 IU — what the leaflet says and what needs checking before the injection

Dibase 100,000 IU/ml is a solution for injection of cholecalciferol (vitamin D3) in olive oil, with 2.5 mg of vitamin D3 in a 1 ml ampoule; the manufacturer's leaflet indicates it for treating vitamin D deficiency in adults, intramuscularly, and contraindicates it in hypercalcaemia, kidney stones and kidney failure. Before a 100,000 IU dose, what matters is your measured level of 25-OH vitamin D, not what you can find in a pharmacy.

What Dibase is

Dibase is made by Abiogen Pharma, in Italy. It comes in two injectable strengths — 100,000 IU/ml and 300,000 IU/ml — and, in Italy, under the same name, in oral forms as well.

According to the package-leaflet databases, in Romania it held marketing authorisation 592/2021, with Imeco as the holder, and was dispensed on a medical prescription that is retained by the pharmacy and cannot be refilled. It is not a supplement.

Where to find it — what we checked

Searches often come with the name of a pharmacy attached: "Dibase Farmacia Tei" (Farmacia Tei is a well-known Romanian pharmacy), "vitamin D3 injection pharmacy". We do not check pharmacy stock and we do not recommend where to buy.

What we did check: in the ANM Nomenclature (the official register of medicines authorised in Romania), consulted on 13 September 2026, Dibase does not appear, whether searched by name or by product code. For plain cholecalciferol, our search returned oral forms — drops and tablets. The register is updated and pharmacy availability changes; ask the pharmacist and, above all, check the leaflet of the product you actually receive. If you are given another injectable vitamin D3 preparation, the strength per millilitre may be different, and the real dose is read from the box, not from the name you searched for.

What the leaflet says

We read the Dibase 100,000 and 300,000 IU leaflet published in Italy, the manufacturer's country (a document made available by the Italian medicines agency, 2022). The Romanian leaflet may differ in details, but the substance, the contraindications and the risks are the same.

Composition: cholecalciferol 2.5 mg, equivalent to 100,000 IU, in one ampoule; the other ingredient is refined olive oil for injection. Indication: treatment of vitamin D deficiency in adults, over 18 years of age. Administration: intramuscular injection. The leaflet states that intramuscular therapy is indicated in malabsorption syndromes. Some older descriptions of the product also mentioned oral use — one more reason to read the leaflet in the box. Doses, in brief:

At these doses, the product is not recommended for children and adolescents under 18, in pregnancy or during breastfeeding.

Contraindications:

• allergy to cholecalciferol or to olive oil;
• high calcium in the blood (hypercalcaemia) or in the urine (hypercalciuria);
• kidney stones or calcium deposits in the kidneys;
• kidney failure.

Situations in which the doctor may ask for regular blood tests: long-term treatment with high doses, older people taking digitalis medicines or diuretics, sarcoidosis. Situations in which higher doses may be needed: treatment with anticonvulsants or corticosteroids, medicines that lower blood fats (colestyramine, orlistat), obesity, diseases with malabsorption, liver failure.

Pregnancy, alcohol and a missed dose

Three points in the leaflet that are rarely read. Pregnancy: excess vitamin D in the first six months of pregnancy can seriously harm the foetus, which is why the 100,000 and 300,000 IU doses are not recommended; because deficiency is also harmful to mother and child, the doctor prescribes lower doses when needed. Breastfeeding: vitamin D and its metabolites pass into breast milk, which is taken into account if the baby is also receiving vitamin D. Alcohol: heavy, chronic drinking lowers the vitamin D stores in the liver. And if a dose has been missed, the leaflet says clearly not to double the next dose.

Why the dose is decided on the basis of 25-OH vitamin D

The main indicator of vitamin D status is the serum concentration of 25-OH vitamin D. The fact sheet for health professionals from the US National Institutes of Health (NIH) summarises the reference positions:

• 50 nmol/L (20 ng/mL) or more — adequate for most people, according to the Food and Nutrition Board;
• below 30 nmol/L (12 ng/mL) — the risk of deficiency increases.

Two nuances from the same source, which we state so that they are not misread:

• results vary between laboratories, depending on the method used, so a value can come out falsely low or falsely high;
• routine screening of adults without symptoms has no evidence of improving health outcomes.

We will not diagnose you on the basis of a figure in an article. The purpose of the test is different: a 100,000 IU dose makes sense when there is a deficiency, and the size of the deficiency changes the decision.

Hypercalcaemia: the risk that searching by pharmacy ignores

Vitamin D is fat-soluble and accumulates. Unlike water-soluble vitamins, the surplus is not quickly eliminated in the urine.

The leaflet describes the symptoms of overdose, caused by the rise of calcium in the blood and urine:

• nausea, vomiting;
• intense thirst and frequent urination;
• constipation and dehydration.

In the long term, excessive doses can lead to deposits of calcium salts in blood vessels and organs. Nephrocalcinosis and kidney failure are also among the adverse reactions reported with vitamin D.

The risk increases when doses add up from different sources. The leaflet asks the doctor to know whether you are also taking other vitamin D products or fortified foods, so that the total dose can be calculated. Interactions that require monitoring include thiazide diuretics, digitalis medicines, magnesium preparations and warfarin.

Oral or injectable

For most people, oral vitamin D is enough — it is simpler, cheaper and easy to adjust. We say this even though we give the injectable form.

The intramuscular route makes sense in specific situations: malabsorption, as the leaflet itself states, difficulty sticking to an oral schedule, or a significant, confirmed deficiency that has to be corrected within a defined time frame. Conversely, an injection does not replace follow-up: if the dose was high or the treatment is ongoing, the doctor may ask for further tests, and their timing is set from the start. More on the difference between the 100,000 and 300,000 IU doses in vitamin D3 injection: where to find it.

How we work

We give injectable vitamin D intramuscularly, only after a medical assessment:

• vitamin D 100,000 IU — 200 RON;
• vitamin D 300,000 IU — 250 RON.

Prices include the assessment. Measuring 25-OH vitamin D beforehand is recommended; if you have recent results, bring them. At the assessment we ask about kidney stones and kidney disease, about pregnancy, about medicines such as diuretics or digitalis and about all the vitamin D supplements you already take, so that the total dose is known. The injection takes a few minutes, at the clinic or at home. Details: vitamin D injection.

We do not sell ampoules, we do not recommend self-administration and we do not set doses by message, on the basis of a lab report sent remotely.

Sources

Foglio illustrativo DIBASE 100,000 U.I./ml and 300,000 U.I./ml soluzione iniettabile — the Italian leaflet (in Italian), AIFA document, 2022: composition, indication, doses, contraindications, overdose.

DIBASE 100,000 IU/ml solution for injection — authorisation data, prospecte.ro: the holder and the authorisation number in Romania, the prescription status.

Nomenclature of medicinal products for human use, ANM (in Romanian), consulted on 13 September 2026.

Vitamin D — Fact Sheet for Health Professionals, NIH Office of Dietary Supplements: 25-OH vitamin D as the indicator, reference thresholds, variability between laboratories.

Informational article. It does not interpret lab results and does not replace a medical consultation; the vitamin D dose is set by a doctor, on the basis of the measured level.